2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

Base Information

Chemical Name:2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone
CAS No.:1005515-18-3
Molecular Formula:C₉H₉BrF₅NOS
Molecular Weight:354.139
Hs Code.:

Synonyms:2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

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Chemical Property of 2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

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Technology Process of 2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

There total 16 articles about 2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178584-47-8
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

: 1005515-18-3
2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide; With sulfuric acid; water; at 80 ℃; Inert atmosphere; Cooling with ice;

With sodium hydroxide; In ethyl acetate;

Reference yield:

: 1005514-91-9
[3-(2-bromo-1,1-dimethoxyethyl)-5-pentafluorosulfanylphenyl]methylamine

: 1005515-18-3
2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: [3-(2-bromo-1,1-dimethoxyethyl)-5-pentafluorosulfanylphenyl]methylamine; With sulfuric acid; water; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water; at 0 ℃; pH=8;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1005515-18-3
2-bromo-1-[3-methylamino-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 75 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Reflux

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

4.1: hydrogen / Raney nickel / methanol / 5 h

5.1: triethylamine / dichloromethane / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

6.2: 2 h / 20 °C / Cooling with ice

6.3: Cooling

7.1: potassium carbonate / 1,2-dimethoxyethane / 0.67 h / 100 °C / microwave irradiation

8.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 20 - 60 °C

9.1: water; sulfuric acid / 7 h / 80 °C / Cooling with ice

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; water; hydrogen; nitric acid; phenyltrimethylammonium tribromide; potassium carbonate; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;