N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

Base Information

Chemical Name:N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide
CAS No.:1178584-95-6
Molecular Formula:C₁₁H₉F₈NO₂S
Molecular Weight:371.251
Hs Code.:

Synonyms:N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

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Chemical Property of N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

There total 8 articles about N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005515-05-8
N-(3-acetyl-5-pentafluorosulfanylphenyl)-2,2,2-trifluoroacetamide

: 74-88-4
methyl iodide

: 1178584-95-6
N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: With potassium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 0.666667h; microwave irradiation;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1178584-95-6
N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / 75 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Reflux

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

4.1: hydrogen / Raney nickel / methanol / 5 h

5.1: triethylamine / dichloromethane / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

6.2: 2 h / 20 °C / Cooling with ice

6.3: Cooling

7.1: potassium carbonate / 1,2-dimethoxyethane / 0.67 h / 100 °C / microwave irradiation

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; hydrogen; nitric acid; potassium carbonate; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 852469-45-5
3-nitro-5-(pentafluoro-λ⁶-sulfanyl)benzoic acid

: 1178584-95-6
N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 20 °C / Reflux

2.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

3.1: hydrogen / Raney nickel / methanol / 5 h

4.1: triethylamine / dichloromethane / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

5.2: 2 h / 20 °C / Cooling with ice

5.3: Cooling

6.1: potassium carbonate / 1,2-dimethoxyethane / 0.67 h / 100 °C / microwave irradiation

With thionyl chloride; N,N-diethyl-N-isopropylamine; hydrogen; potassium carbonate; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;