1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
CAS No.:1280206-27-0
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

There total 7 articles about 1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280206-27-0
1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2: lithium borohydride; ethanol / 60 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

With lithium borohydride; ethanol; hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; 3: Suzuki Coupling;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1280206-27-0
1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride; ethanol / 60 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

With lithium borohydride; ethanol; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; 2: Suzuki Coupling;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1280206-27-0
1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 2.17 h / 20 °C

2.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C

2.2: Acidic conditions

3.1: sulfuric acid / 1 h / 75 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

With sulfuric acid; tetrabutylammomium bromide; potassium acetate; sodium hydrogencarbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; ethylene glycol; toluene; 5.1: Suzuki Coupling;