N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Base Information

Chemical Name:N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester
CAS No.:113266-05-0
Molecular Formula:C₄₈H₅₁N₅O₁₁
Molecular Weight:873.96
Hs Code.:

Synonyms:N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

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Chemical Property of N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

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Technology Process of N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

There total 18 articles about N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 113266-09-4
N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

: 113266-05-0
N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 113266-05-0
N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DCCI / tetrahydrofuran / 0 °C

2: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

3: 70 percent / TFA / CH₂Cl₂ / 1.5 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 113247-73-7
N-fluorenylmethoxycarbonyl-O-t-butyl-D-serylglycyne benzyl ester

: 113266-05-0
N-benzyloxycarbonyl-O-benzyl-L-tyrosyl-O-t-butyl-D-serylglycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DCCI / tetrahydrofuran / 0 °C

2: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

3: 93 percent / H₂ / Pd/C / ethanol; ethyl acetate / 1 h

4: DCCI / tetrahydrofuran / 0 °C

5: N,N-diisopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

6: piperidine / dimethylformamide / 0.17 h / Ambient temperature

7: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

8: 70 percent / TFA / CH₂Cl₂ / 1.5 h / Ambient temperature

With piperidine; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;