113247-73-7Relevant academic research and scientific papers
Obstacles and solutions for chemical synthesis of syndecan-3 (53–62) glycopeptides with two heparan sulfate chains
Yang, Weizhun,Yoshida, Keisuke,Yang, Bo,Huang, Xuefei
supporting information, p. 180 - 194 (2016/11/09)
Proteoglycans play critical roles in many biological events. Due to their structural complexities, strategies towards synthesis of this class of glycopeptides bearing well-defined glycan chains are urgently needed. In this work, we give the full account o
Studies on Conformationally Restricted, Disiloxane Bridged Analogues of the Enkephalins
Davies, John S.,Tremeer, E. John,Treadgold, Richard C.
, p. 1107 - 1116 (2007/10/02)
Solution-phase synthesis of protected 2, Ser5>- and 2, Ser5>-enkephalins, followed by treatment with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane i2Si(Cl)-O-Si(Cl)Pri2> in base have yielded cyclic bridged disiloxane analogues showing biological activity in an in vitro assay.Highfield (1)H n.m.r. studies augmented by n.O.e. difference spectroscopy, temperature dependence studies of the amide protons, and the use of computer graphics support the presence of a 2-->5 H-bonded β-bend conformation for the most biologically potent of the cyclic analogues.
