N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

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Chemical Name:N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide
CAS No.:1256488-46-6
Molecular Formula:C₂₆H₃₀N₂O₅S
Molecular Weight:482.601
Hs Code.:

Synonyms:N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

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Technology Process of N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

There total 13 articles about N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1256488-98-8
C₂₆H₃₂N₂O₆S

: 1256488-46-6
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

Guidance literature:: C₂₆H₃₂N₂O₆S; With phosphoric acid; In tetrahydrofuran; water; at 100 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; water; pH=~ 6; Cooling with ice;

Reference yield:

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 1256488-46-6
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; bis(pinacol)diborane / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 26 h / 70 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

4.1: phosphoric acid / tetrahydrofuran; water / 100 °C

4.2: pH ~ 6 / Cooling with ice

With lithium aluminium tetrahydride; phosphoric acid; potassium acetate; sodium carbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 856898-35-6
methyl 2-bromo-5-[(methylsulfonyl)amino]benzoate

: 1256488-46-6
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-isochroman-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / Inert atmosphere

1.2: 6 h / 75 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -30 - 20 °C

3.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 70 °C

4.1: gold(III) chloride / trifluoroacetic acid / 0.75 h / 100 °C / Sealed tube; Microwave Irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

7.1: phosphoric acid / tetrahydrofuran; water / 100 °C

7.2: pH ~ 6 / Cooling with ice

With copper(l) iodide; lithium aluminium tetrahydride; phosphoric acid; tetrabutyl ammonium fluoride; sodium carbonate; triethylamine; gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;