[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

Base Information

Chemical Name:[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane
CAS No.:705297-38-7
Molecular Formula:C₂₄H₃₃IOSeSi
Molecular Weight:571.475
Hs Code.:

Synonyms:[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

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Chemical Property of [2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

Chemical Property:

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Technology Process of [2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

There total 6 articles about [2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 705297-37-6
2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethanol

: 705297-38-7
[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jo049873s

Reference yield:

: 1666-13-3
diphenyl diselenide

: 705297-38-7
[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaBH₄ / ethanol

1.2: 77 percent / 1,2-dimethoxy-ethane / 16 h / Heating

2.1: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo049873s

Reference yield:

: 40400-13-3
2-Iodobenzyl bromide

: 705297-38-7
[2-(2-iodobenzyl)-1-(trans-3-phenylselanylcyclobutyl)ethoxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibromoethane; Zn powder / tetrahydrofuran / 5 °C

1.2: 40 percent / CuCN; LiCl / tetrahydrofuran / 0.5 h / -20 °C

2.1: 93 percent / NaBH₄ / methanol / 5 h / 25 °C

3.1: NaBH₄ / ethanol

3.2: 77 percent / 1,2-dimethoxy-ethane / 16 h / Heating

4.1: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; 1,1-Dibromoethane; zinc; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo049873s