di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate
CAS No.:444667-51-0
Molecular Formula:C₃₆H₆₆N₂O₈Si₂
Molecular Weight:711.1
Hs Code.:

Synonyms:di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

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Chemical Property of di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

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Technology Process of di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

There total 7 articles about di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 444667-50-9
C₂₃H₄₂ClNO₄Si₂

: 16874-06-9
di-tert-butyl L-glutamate

: 444667-51-0
di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;
DOI:10.1016/j.tetlet.2005.08.003

Reference yield:

: 444667-48-5
4-benzyloxy-N,N-bis(2-(tert-butyldimethylsilyloxy)ethyl)aniline

: 444667-51-0
di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran

2: Et₃N / toluene / 0.17 h / 20 °C

3: 90 percent / Et₃N / tetrahydrofuran / 0.08 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetlet.2005.08.003

Reference yield:

: 101582-69-8
4--O-benzylphenol

: 444667-51-0
di-tert-butyl N-{4-[N,N-bis(2'-(tert-butyldimethylsilyloxy)ethyl)amino]phenoxycarbonyl}-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / imidazole / dimethylformamide

2: 100 percent / H₂ / Pd/C / tetrahydrofuran

3: Et₃N / toluene / 0.17 h / 20 °C

4: 90 percent / Et₃N / tetrahydrofuran / 0.08 h / 20 °C

With 1H-imidazole; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2005.08.003