2,4-Difluoro-3-methoxybenzylamine

Base Information

Chemical Name:2,4-Difluoro-3-methoxybenzylamine
CAS No.:717094-51-4
Molecular Formula:C8H9 F2 N O
Molecular Weight:173.1599664
Hs Code.:2922299090
DSSTox Substance ID:DTXSID40394314
Wikidata:Q82193618
Mol file:717094-51-4.mol

Synonyms:2,4-Difluoro-3-methoxybenzylamine;717094-51-4;(2,4-difluoro-3-methoxyphenyl)methanamine;SCHEMBL8274219;BENZENEMETHANAMINE, 2,4-DIFLUORO-3-METHOXY- (9CI);DTXSID40394314;AAZMLHVLBRWOGC-UHFFFAOYSA-N;2,4 difluoro-3-methoxybenzylamine;MFCD04115935;AKOS015956691;JS-4284;CS-0315638;2,4-Difluoro-3-methoxybenzylamine, AldrichCPR;D78500;A866380;1-(2,4-DIFLUORO-3-METHOXYPHENYL)METHANAMINE

Suppliers and Price of 2,4-Difluoro-3-methoxybenzylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2,4-Difluoro-3-methoxybenzylamine
10 g
$ 720.00

SynQuest Laboratories
2,4-Difluoro-3-methoxybenzylamine
5 g
$ 397.00

Matrix Scientific
2,4-Difluoro-3-methoxybenzylamine
5g
$ 515.00

Matrix Scientific
2,4-Difluoro-3-methoxybenzylamine
10g
$ 920.00

Crysdot
2,4-Difluoro-3-methoxybenzylamine 95+%
10g
$ 920.00

Crysdot
2,4-Difluoro-3-methoxybenzylamine 95+%
5g
$ 515.00

American Custom Chemicals Corporation
2,4-DIFLUORO-3-METHOXYBENZYLAMINE 95.00%
5G
$ 962.92

American Custom Chemicals Corporation
2,4-DIFLUORO-3-METHOXYBENZYLAMINE 95.00%
10G
$ 1392.24

Alichem
2,4-Difluoro-3-methoxybenzylamine
10g
$ 966.00

Alichem
2,4-Difluoro-3-methoxybenzylamine
5g
$ 504.70

Total 9 raw suppliers

Chemical Property of 2,4-Difluoro-3-methoxybenzylamine

Chemical Property:

Refractive Index:1.4980
PSA：35.25000
LogP:2.13240
Sensitive.:Air Sensitive
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:173.06522023
Heavy Atom Count:12
Complexity:145

Purity/Quality:

98% ^*data from raw suppliers

2,4-Difluoro-3-methoxybenzylamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1F)CN)F

Technology Process of 2,4-Difluoro-3-methoxybenzylamine

There total 7 articles about 2,4-Difluoro-3-methoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 658-07-1
2,6-Difluoro-4-nitrophenol

: 717094-51-4
(2,4-difluoro-3-methoxyphenyl)methanamine

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃ / acetone / 6 h / Heating

2: 99 percent / H₂ / 10 percent Pd/C / ethyl acetate

3: 64 percent / I₂, aq. NaHCO₃ / Ambient temperature

4: 1.) aq. NaNO₂, H₂SO₄, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h

5: 83 percent / dimethylformamide / 22 h / 120 - 140 °C

6: BH₃*THF / tetrahydrofuran / 10 h / Heating

With borane-THF; sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm980435l

Reference yield:

: 28177-48-2
2,6-difluorophenol

: 717094-51-4
(2,4-difluoro-3-methoxyphenyl)methanamine

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / HNO₃ / acetic acid / 15 - 20 °C

2: 94 percent / K₂CO₃ / acetone / 6 h / Heating

3: 99 percent / H₂ / 10 percent Pd/C / ethyl acetate

4: 64 percent / I₂, aq. NaHCO₃ / Ambient temperature

5: 1.) aq. NaNO₂, H₂SO₄, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h

6: 83 percent / dimethylformamide / 22 h / 120 - 140 °C

7: BH₃*THF / tetrahydrofuran / 10 h / Heating

With borane-THF; sulfuric acid; hydrogen; iodine; nitric acid; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm980435l

Reference yield:

: 392-25-6
1,3-difluoro-2-methoxy-5-nitrobenzene

: 717094-51-4
(2,4-difluoro-3-methoxyphenyl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / H₂ / 10 percent Pd/C / ethyl acetate

2: 64 percent / I₂, aq. NaHCO₃ / Ambient temperature

3: 1.) aq. NaNO₂, H₂SO₄, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h

4: 83 percent / dimethylformamide / 22 h / 120 - 140 °C

5: BH₃*THF / tetrahydrofuran / 10 h / Heating

With borane-THF; sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980435l