2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile
• CAS No.: 202349-60-8
• Molecular Formula: C₁₀H₈N₂OS₂
• Molecular Weight: 236.318

Synonyms:2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

Chemical Property of 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

Chemical Property:

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Technology Process of 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

There total 2 articles about 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + cycl-isopropylidene malonate (2033-24-1) + Cyanothioacetamide (7357-70-2) → 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile (202349-60-8)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; Yield given. Multistep reaction; 1.) EtOH, reflux, 3 h, 2.) EtOH, 12 h;

DOI:10.1007/BF02495131

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + 1,5-dioxaspiro[5.5]undecane-2,4-dione (1658-27-1) + Cyanothioacetamide (7357-70-2) → 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile (202349-60-8)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; Yield given. Multistep reaction; 1.) EtOH, reflux, 3 h, 2.) EtOH, 12 h;

DOI:10.1007/BF02495131

Reference yield: 72.0%

N-chloroacetyl-aniline (587-65-5) + 2-Mercapto-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile (202349-60-8) → 2-(3-Cyano-6-oxo-4-thiophen-2-yl-1,4,5,6-tetrahydro-pyridin-2-ylsulfanyl)-N-phenyl-acetamide

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; for 2h;

DOI:10.1007/BF02495131

upstream raw materials:

thiophene-2-carbaldehyde

cycl-isopropylidene malonate

Cyanothioacetamide

1,5-dioxaspiro[5.5]undecane-2,4-dione

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