4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

Base Information

Chemical Name:4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine
CAS No.:1283629-17-3
Molecular Formula:C₂₃H₂₂F₃N₃O₂
Molecular Weight:429.442
Hs Code.:

Synonyms:4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

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Technology Process of 4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

There total 5 articles about 4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 696-57-1
N-allylmorpholine

: 1283629-00-4
1-(3-(trifluoromethyl)phenyl)-1H-indole-3-carbaldehyde oxime

: 1283629-17-3
4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

Guidance literature:: With sodium hypochlorite; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.127

Reference yield:

: 120-72-9
indole

: 1283629-17-3
4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 3 h / 165 °C

2.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 164 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride / pyridine; ethanol / 16 h / 20 °C / Inert atmosphere

4.1: sodium hypochlorite / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium hypochlorite; copper(l) iodide; hydroxylamine hydrochloride; caesium carbonate; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.127

Reference yield:

: 1-(3-(trifluoromethyl)phenyl)-1H-indole

: 1283629-17-3
4-((3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-4,5-dihydroisoxazol-5-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere

1.2: 2 h / 164 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / pyridine; ethanol / 16 h / 20 °C / Inert atmosphere

3.1: sodium hypochlorite / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium hypochlorite; hydroxylamine hydrochloride; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1016/j.bmcl.2010.12.127