(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

Base Information

Chemical Name:(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol
CAS No.:91712-55-9
Molecular Formula:C₂₃H₂₈O₅S
Molecular Weight:416.538
Hs Code.:

Synonyms:(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

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Chemical Property of (R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

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Technology Process of (R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

There total 8 articles about (R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 91741-62-7
2-[(E)-(S)-1-Hydroxy-4,4-dimethoxy-3-methyl-2-((R)-toluene-4-sulfinyl)-but-2-enyl]-3,5,6-trimethyl-benzene-1,4-diol

: 91712-55-9
(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

Guidance literature:: With sodium methylate; In methanol; for 3h; Heating;
DOI:10.1021/ja00332a066

Reference yield:

: 10439-23-3
4-methylbenzenesulfinyl chloride

: 91712-55-9
(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1) pyridine, 2) HCl / 1) Et₂O, 0 deg C; 2) acetone

2: 50 percent / n-BuLi / tetrahydrofuran / -78 °C

3: 1) n-BuLi, 2) LDA / 1) THF, -78 deg C; 2) THF, -100 deg C, 3 min

4: 75 percent / tetrahydrofuran / 2 h / -78 °C

5: 60 percent / (n-Bu)4NF / tetrahydrofuran / 2 h / Ambient temperature

6: 96 percent / MeONa / methanol / 3 h / Heating

With pyridine; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ja00332a066

Reference yield:

: 6342-56-9
Pyruvic aldehyde dimethyl acetal

: 91712-55-9
(R)-2-Dimethoxymethyl-2,5,7,8-tetramethyl-3-((R)-toluene-4-sulfinyl)-2H-chromen-6-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi, 2) LDA / 1) THF, -78 deg C; 2) THF, -100 deg C, 3 min

2: 75 percent / tetrahydrofuran / 2 h / -78 °C

3: 60 percent / (n-Bu)4NF / tetrahydrofuran / 2 h / Ambient temperature

4: 96 percent / MeONa / methanol / 3 h / Heating

With n-butyllithium; tetrabutyl ammonium fluoride; sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ja00332a066