6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Base Information

Chemical Name:6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole
CAS No.:1613505-20-6
Molecular Formula:C₂₁H₂₁F₃N₂O₂
Molecular Weight:390.405
Hs Code.:

Synonyms:6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Suppliers and Price of 6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

There total 5 articles about 6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1613505-19-3
(1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl)methanol

: 74-88-4
methyl iodide

: 1613505-20-6
6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Guidance literature:: (1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jm401986p

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1613505-20-6
6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Cooling with ice

2.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere

2.2: 20 °C

3.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

6.2: 1.5 h / 0 - 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil; 4.1: |Suzuki Coupling;
DOI:10.1021/jm401986p

Reference yield:

: 474330-54-6
5-amino-2-bromo-4-methylbenzoic acid methyl ester

: 1613505-20-6
6-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

5.2: 1.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling;
DOI:10.1021/jm401986p