Technology Process of (S,Z)-tert-butyl 4-(2-formamidostyryl)-2,2-dimethyloxazolidine-3-carboxylate
There total 6 articles about (S,Z)-tert-butyl 4-(2-formamidostyryl)-2,2-dimethyloxazolidine-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ethylene dibromide; zinc;
In
2,2,2-trifluoroethanol;
at 70 ℃;
for 1h;
Inert atmosphere;
With
copper(I) bromide; lithium bromide;
In
tetrahydrofuran; 2,2,2-trifluoroethanol;
at 70 ℃;
Inert atmosphere;
(S)-tert-butyl 4-((2-formamidophenyl)ethynyl)-2,2-dimethyloxazolidine-3-carboxylate;
In
tetrahydrofuran; 2,2,2-trifluoroethanol;
at 70 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.201004963
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / dichloromethane / 0.67 h / -30 °C / Inert atmosphere
1.2: 2.5 h / -60 - 0 °C / Inert atmosphere
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 2.33 h / 0 °C / Inert atmosphere
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere
4.1: ethylene dibromide; copper(I) bromide; lithium bromide; zinc / 2,2,2-trifluoroethanol / 3 h / 70 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; ethylene dibromide; triethylamine; triphenylphosphine; copper(I) bromide; lithium bromide; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; 2,2,2-trifluoroethanol;
3.1: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.112
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic anhydride / 1 h / 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere
3.1: ethylene dibromide; copper(I) bromide; lithium bromide; zinc / 2,2,2-trifluoroethanol / 3 h / 70 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic anhydride; ethylene dibromide; triethylamine; copper(I) bromide; lithium bromide; zinc;
In
2,2,2-trifluoroethanol;
2.1: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.112
