D-glycine tert-butyl ester toluenesulfonate salt

Base Information

• Chemical Name: D-glycine tert-butyl ester toluenesulfonate salt
• CAS No.: 123004-72-8
• Molecular Formula: C₇H₈O₃S*C₁₉H₂₃NO₃
• Molecular Weight: 485.601
• Mol file: 123004-72-8.mol

Synonyms:D-glycine tert-butyl ester toluenesulfonate salt

Chemical Property of D-glycine tert-butyl ester toluenesulfonate salt

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of D-glycine tert-butyl ester toluenesulfonate salt

There total 1 articles about D-glycine tert-butyl ester toluenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

D-2-[p-(benzyloxy)phenyl]glycine (69489-40-3) + toluene-4-sulfonic acid (104-15-4) + isobutene (115-11-7,15220-85-6) → D-glycine tert-butyl ester toluenesulfonate salt (123004-72-8)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jo4007893

Reference yield: 95.0%

D-glycine tert-butyl ester toluenesulfonate salt (123004-72-8) + L-Ox-serine dicyclohexylammonium salt → tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate (111216-46-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1.) 0 deg C, 2.5 h, 2.) RT, 1.5 h;

DOI:10.1021/ja00158a040

Reference yield: 69.0%

D-glycine tert-butyl ester toluenesulfonate salt (123004-72-8) + L-Ox-serine dicyclohexylammonium salt (40719-42-4) → (-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester (110207-46-0)

Guidance literature:

L-Ox-serine dicyclohexylammonium salt; With (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0166667h;

D-glycine tert-butyl ester toluenesulfonate salt; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo4007893

upstream raw materials:

D-2-[p-(benzyloxy)phenyl]glycine

toluene-4-sulfonic acid

isobutene

Downstream raw materials:

tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

(-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester

(-)-tert-butyl 3-aminonocardicinate hydrochloride

(R)-{(S)-3-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-oxo-azetidin-1-yl}-(4-hydroxy-phenyl)-acetic acid tert-butyl ester