N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Base Information

Chemical Name:N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
CAS No.:1356010-29-1
Molecular Formula:C₂₅H₂₄Cl₂N₆O
Molecular Weight:495.411
Hs Code.:

Synonyms:N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Chemical Property of N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Technology Process of N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

There total 14 articles about N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.24%

: 1356009-74-9
2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

: 1356010-29-1
N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: With iron; ammonium chloride; In methanol; at 65 ℃; for 5h;

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1356010-29-1
N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere

2: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

3: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C

4: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

6: ammonium chloride; iron / methanol / 5 h / 65 °C

With hydrogenchloride; boron tribromide; iron; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 619-10-3
5-nitro-2-chlorophenol

: 1356010-29-1
N-(3-(5-amino-2-(4-chloro-1H-imidazol-1-yl)phenoxy)propyl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

5: ammonium chloride; iron / methanol / 5 h / 65 °C

With hydrogenchloride; iron; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;