trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

Base Information

Chemical Name:trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester
CAS No.:865087-54-3
Molecular Formula:C₁₆H₁₆F₃NO₃S
Molecular Weight:359.369
Hs Code.:

Synonyms:trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

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Chemical Property of trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

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Technology Process of trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

There total 8 articles about trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

: 865087-46-3
4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenol

: 358-23-6
trifluoromethylsulfonic anhydride

: 865087-54-3
trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

Guidance literature:: With pyridine; at 20 ℃; for 6h;
DOI:10.1021/ol051365x DOI:10.1021/ja0674690

Reference yield:

: 70564-92-0
4-bromo-3,5-dimethyl-pyridine 1-oxide

: 865087-54-3
trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / K₃PO₄; dicyclohexyl-(2-phenanthren-6-yl-phenyl)phosphane / Pd₂(dba)3 / toluene / 48 h / 120 °C

2: 97.9 percent / NaH₂PO₂; AcOH / Pd/C / 12 h / 80 °C

3: 91.6 percent / pyridine*HCl / 3 h / 210 °C

4: 92.8 percent / pyridine / 6 h / 20 °C

With pyridine; potassium phosphate; sodium hypophosphite; pyridine hydrochloride; acetic acid; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; 1: Suzuki coupling;
DOI:10.1021/ja0674690

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 865087-54-3
trifluoromethane sulfonic acid 4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / K₂CO₃ / acetone / 8 h / 65 °C

2.1: N-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 °C

2.2: 83 percent / triisopropyl borate / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 53 percent / K₃PO₄; dicyclohexyl-(2-phenanthren-6-yl-phenyl)phosphane / Pd₂(dba)3 / toluene / 48 h / 120 °C

4.1: 97.9 percent / NaH₂PO₂; AcOH / Pd/C / 12 h / 80 °C

5.1: 91.6 percent / pyridine*HCl / 3 h / 210 °C

6.1: 92.8 percent / pyridine / 6 h / 20 °C

With pyridine; potassium phosphate; sodium hypophosphite; n-butyllithium; pyridine hydrochloride; potassium carbonate; acetic acid; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; acetone; toluene; 3.1: Suzuki coupling;
DOI:10.1021/ja0674690