N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Base Information

Chemical Name:N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine
CAS No.:107755-79-3
Molecular Formula:C₃₀H₃₈N₄O
Molecular Weight:470.658
Hs Code.:

Synonyms:N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

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Chemical Property of N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

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Technology Process of N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

There total 6 articles about N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 101620-10-4
4-(4-diphenyl-methyl-1-piperazinyl)butylamine

: 118420-23-8
3-(6-Methyl-3-pyridyl)propionic acid

: 107755-79-3
N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00123a012

Reference yield:

: 53014-84-9
2-methyl-5-formylpyridine

: 107755-79-3
N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / piperidine / pyridine / 100 °C

2: 75 percent / hydrogen / 10 percent Pd/C / methanol; dimethylformamide / 760 Torr / Ambient temperature

3: 37 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a012

Reference yield:

: 34107-46-5
6-methyl-3-pyridinemethanol

: 107755-79-3
N-[3-(6-methyl-pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / Pb(OAc)4 / toluene / 2.5 h / Heating

2: 77 percent / piperidine / pyridine / 100 °C

3: 75 percent / hydrogen / 10 percent Pd/C / methanol; dimethylformamide / 760 Torr / Ambient temperature

4: 37 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With piperidine; lead(IV) acetate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00123a012