(R)-flurbiprofen di(1-naphthyl)methyl ester

Base Information

Chemical Name:(R)-flurbiprofen di(1-naphthyl)methyl ester
CAS No.:1116086-49-7
Molecular Formula:C₃₆H₂₇FO₂
Molecular Weight:510.608
Hs Code.:

Synonyms:(R)-flurbiprofen di(1-naphthyl)methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-flurbiprofen di(1-naphthyl)methyl ester

Chemical Property:

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Technology Process of (R)-flurbiprofen di(1-naphthyl)methyl ester

There total 3 articles about (R)-flurbiprofen di(1-naphthyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5104-49-4
fluorobiprofen

: 62784-66-1
bis(1-naphthyl)methanol

: 1116086-49-7
(R)-flurbiprofen di(1-naphthyl)methyl ester

: (S)-flurbiprofen di(1-naphthyl)methyl ester

: 5104-49-4,51543-38-5,51543-39-6,51543-40-9
(S)-(+)-flurbiprofen

: 5104-49-4,51543-38-5,51543-39-6,51543-40-9
(R)-flurbiprofen

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; p-Methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;
DOI:10.1002/ejoc.200800942

Reference yield:

: 185981-25-3
C₃₀H₂₄F₂O₃

: 62784-66-1
bis(1-naphthyl)methanol

: 1116086-49-7
(R)-flurbiprofen di(1-naphthyl)methyl ester

: (S)-flurbiprofen di(1-naphthyl)methyl ester

: 5104-49-4,51543-38-5,51543-39-6,51543-40-9
(S)-(+)-flurbiprofen

: 5104-49-4,51543-38-5,51543-39-6,51543-40-9
(R)-flurbiprofen

Guidance literature:: With 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine; In toluene; at 0 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.200900451

Reference yield:

: 1116086-49-7
(R)-flurbiprofen di(1-naphthyl)methyl ester

: (S)-flurbiprofen di(1-naphthyl)methyl ester

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 48h; Overall yield = 89 %;