Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI)

Base Information

• Chemical Name: Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI)
• CAS No.: 711601-13-7
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.244
• Hs Code.: 2933499090
• Mol file: 711601-13-7.mol

Synonyms:Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI)

Chemical Property of Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI)

Chemical Property:

• PSA: 49.06000
• LogP: 2.43390

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI)

There total 5 articles about Isoquinoline, 2-ethyl-1,2,3,4-tetrahydro-7-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

7-nitro-1,2,3,4-tetrahydroisoquinoline (42923-79-5) + ethyl iodide (75-03-6) → 2-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (711601-13-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

7-nitro-1,2,3,4-tetrahydroisoquinoline (42923-79-5) + acetaldehyde (75-07-0,9002-91-9) → 2-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (711601-13-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetic acid; 1,2-dichloro-ethane; at 25 ℃; for 72h;

DOI:10.1016/S0968-0896(00)00149-8

Reference yield:

2,2,2-Trifluoro-N-(2-(4-nitrophenyl)ethyl)acetamide (24954-63-0) → 2-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (711601-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / conc. H₂SO₄ / acetic acid / 20 h / 25 °C

2: 11 g / K₂CO₃ / methanol; H₂O / 18 h

3: sodium triacetoxyborohydride / 1,2-dichloro-ethane; acetic acid / 72 h / 25 °C

With sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; In methanol; water; acetic acid; 1,2-dichloro-ethane; 1: Cyclization / 2: Hydrolysis / 3: Reduction;

DOI:10.1016/S0968-0896(00)00149-8

upstream raw materials:

7-nitro-1,2,3,4-tetrahydroisoquinoline

acetaldehyde

2,2,2-Trifluoro-N-(2-(4-nitrophenyl)ethyl)acetamide

2,2,2-trifluoro-1-(7-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-ethan-1-one

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