ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

Base Information

Chemical Name:ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate
CAS No.:1262215-63-3
Molecular Formula:C₁₉H₁₈FN₅O₂
Molecular Weight:367.383
Hs Code.:

Synonyms:ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

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Chemical Property of ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

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Technology Process of ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

There total 9 articles about ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1262215-61-1
ethyl N-(3-amino-5-fluoro-4-methylphenyl)carbamate

: 483324-01-2
2-chloro-4-(pyridin-3-yl)pyrimidine

: 1262215-63-3
ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In 1,4-dioxane; for 18h; Heating; Reflux; Inert atmosphere;

Reference yield:

: 1692-25-7
3-pyridylboronic acid

: 1262215-63-3
ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 16 h / Heating; Reflux; Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / Heating; Reflux; Inert atmosphere

With sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 16533-71-4
3,5-dinitro-p-toluic acid

: 1262215-63-3
ethyl N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C

2.1: hydrazine / methanol / 24 h / 20 °C

3.1: sodium nitrite; acetic acid / water; methanol / 0 °C

3.2: 24 h / Heating; Reflux

4.1: sodiumsulfide nonahydrate / ethanol; water / 18 h / 20 °C

5.1: pyridine; sodium nitrite; hydrogen fluoride / water / 0 - 80 °C / Ice/salt bath; Sealed tube

6.1: water; iron / 2 h / 100 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / Heating; Reflux; Inert atmosphere

With pyridine; sodiumsulfide nonahydrate; hydrogen fluoride; water; iron; potassium carbonate; acetic acid; hydrazine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;