1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one

Base Information

• Chemical Name: 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one
• CAS No.: 371943-73-6
• Molecular Formula: C₁₉H₁₉N₃O₃
• Molecular Weight: 337.378
• Mol file: 371943-73-6.mol

Synonyms:1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one

Chemical Property of 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one

There total 1 articles about 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + 1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-one (28096-15-3) → 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one (371943-73-6)

Guidance literature:

In ethanol; at 20 ℃; for 4h; Reflux;

DOI:10.1016/j.poly.2010.10.001

Reference yield: 89.0%

copper(II) nitrate trihydrate + 1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one (371943-73-6) → [Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)(NO3)(H2O)2] (1265897-10-6)

Guidance literature:

In ethanol; water; a soln. of Cu-salt in ethanol-water (2:1 v/v) was added dropwise to a stirred ethanol soln. of pyrazolinone-compound, the soln. was stirred for 3 h at room temp.; ppt. was filtered, washed with hot water, then ethanol followed by etherand dried in vac.; elem. anal.;

DOI:10.1016/j.poly.2010.10.001

Reference yield: 83.0%

1-phenyl-2,3-dimethyl-4-(N-2-hydroxy-4-methoxybenzaldehyde)-3-pyrazolin-5-one (371943-73-6) + copper(II) acetate monohydrate (6046-93-1) → [Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)2] (1265897-12-8)

Guidance literature:

In ethanol; water; a soln. of Cu-salt in ethanol-water (2:1 v/v) was added dropwise to a stirred ethanol soln. of pyrazolinone-compound, the soln. was stirred for 3 h at room temp.; ppt. was filtered, washed with hot water, then ethanol followed by etherand dried in vac.; elem. anal.;

DOI:10.1016/j.poly.2010.10.001

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-one

Downstream raw materials:

[Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)(ClO₄)(H₂O)2]

[Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)Cl(H₂O)]

[Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)(NO₃)(H₂O)2]

[Cu(1-phenyl-2,3-dimethyl-4-(N-2-oxy-methoxybenzaldehyde)-3-pyrazolin-5-one)2]