tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate
CAS No.:917357-95-0
Molecular Formula:C₁₅H₂₁BrN₂O₄S
Molecular Weight:405.313
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

There total 1 articles about tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 122536-77-0,140629-77-2
3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine

: 98-58-8
4-bromobenzenesulfonyl chloride

: 917357-95-0
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 3 - 20 ℃; for 1.66667h;

Reference yield:

: 917357-95-0
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

: 74-88-4
methyl iodide

: 917357-96-1
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}methylcarbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 16h;

Reference yield:

: 917357-95-0
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

: 917356-53-7
2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 - 60 °C

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 19 h / 80 °C

3: dichloromethane / 16 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 84 h / 60 °C

With sodium hydride; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;