2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

Base Information

Chemical Name:2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol
CAS No.:917356-53-7
Molecular Formula:C₁₉H₂₃ClN₂O₃S
Molecular Weight:394.922
Hs Code.:

Synonyms:2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

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Chemical Property of 2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

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Technology Process of 2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

There total 5 articles about 2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 624-76-0
Iodoethanol

: 917357-99-4
(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]-N-methyl-pyrrolidin-3-amine trifluoroacetate

: 917356-53-7
2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 84h; Product distribution / selectivity;

Reference yield:

: 917357-95-0
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}carbamate

: 917356-53-7
2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 - 60 °C

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 19 h / 80 °C

3: dichloromethane / 16 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 84 h / 60 °C

With sodium hydride; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;

Reference yield:

: 917357-96-1
tert-butyl {(3R)-1-[(4-bromo-phenyl)sulfonyl]pyrrolidin-3-yl}methylcarbamate

: 917356-53-7
2-[{(3R)-1-[(4'-chloro-biphenyl-4-yl)sulfonyl]pyrrolidin-3-yl}(methyl)amino]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 19 h / 80 °C

2: dichloromethane / 16 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 84 h / 60 °C

With caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;