2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone

Base Information

• Chemical Name: 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone
• CAS No.: 1375104-81-6
• Molecular Formula: C₂₃H₂₂N₂O₄S
• Molecular Weight: 422.505
• Mol file: 1375104-81-6.mol

Synonyms:2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone

Chemical Property of 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone

There total 4 articles about 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-4'-(N,N-dimethylamino)-benzophenone (1235031-19-2) + 4-methylsulfonylbenzoyl chloride (40913-92-6) → 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone (1375104-81-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.04.022

Reference yield:

2-(Toluene-4-sulfonylamino)-benzoyl chloride (42840-02-8) → 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone (1375104-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 5 h / 0 - 5 °C

2: perchloric acid; acetic acid / 3 h / 100 °C

3: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; perchloric acid; acetic acid; triethylamine; In tetrahydrofuran; 1: Friedel-Crafts acylation;

DOI:10.1016/j.bmc.2012.04.022

Reference yield:

2-(4-methylphenylsulfonamido)-4'-(N,N-dimethylamino)-benzophenone (1375104-80-5) → 2-(4-methylsulfonylbenzoyl)-amino-4'-(N,N-dimethylamino)-benzophenone (1375104-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid; acetic acid / 3 h / 100 °C

2: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With perchloric acid; acetic acid; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmc.2012.04.022

upstream raw materials:

2-amino-4'-(N,N-dimethylamino)-benzophenone

4-methylsulfonylbenzoyl chloride

2-(4-methylphenylsulfonamido)-4'-(N,N-dimethylamino)-benzophenone

N,N-dimethyl-aniline

Downstream raw materials:

C₂₁H₁₆⁽¹⁸⁾FNO₄S

3-(4-[⁽¹⁸⁾F]fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-indole

CF₃O₃S^(1-)*C₂₄H₂₅N₂O₄S⁽¹⁺⁾