4-(Methylsulfonyl)benzoyl chloride

Base Information

• Chemical Name: 4-(Methylsulfonyl)benzoyl chloride
• CAS No.: 40913-92-6
• Molecular Formula: C8H7ClO3S
• Molecular Weight: 218.661
• Hs Code.: 2916399090
• Mol file: 40913-92-6.mol

Synonyms:Benzoyl chloride,4-(methylsulfonyl);4-(methylsulfonyl)benzoyl chloride;4-(methylsulphonyl)benzoyl chloride;4-methanesulfonylbenzoyl chloride;p-(methylsulfonyl)benzoyl chloride;

Chemical Property of 4-(Methylsulfonyl)benzoyl chloride

Chemical Property:

• PSA: 59.59000
• LogP: 2.54990

Purity/Quality:

97% ^*data from raw suppliers

4-(Methylsulphonyl)benzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Methylsulfonyl)benzoyl chloride

There total 14 articles about 4-(Methylsulfonyl)benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methylsulfonylbenzoic acid (4052-30-6) → 4-methylsulfonylbenzoyl chloride (40913-92-6)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Reflux;

DOI:10.1016/j.tet.2016.02.045

Reference yield:

oxalyl dichloride (79-37-8) + 4-methylsulfonylbenzoic acid (4052-30-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-methylsulfonylbenzoyl chloride (40913-92-6)

Guidance literature:

In dichloromethane;

Reference yield:

4-methylphenyl methylsulfide (623-13-2) → 4-methylsulfonylbenzoyl chloride (40913-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: KMnO₄, aq. NaOH

2: SOCl₂ / tetrahydrofuran

With sodium hydroxide; potassium permanganate; thionyl chloride; In tetrahydrofuran;

DOI:10.1021/jm00311a024

upstream raw materials:

4-methylsulfonylbenzoic acid

N-(4-methanesulfonylphenyl)acetamide

4-methanesulfonylphenylamine

4-(methylsulfonyl)benzonitrile

Downstream raw materials:

4-methanesulfonyl-benzoic acid-[5-(4-nitro-phenoxy)-pentylamide]

methyl 4-(methanesulfonyl)benzoate

3-(4-methanesulfonyl-phenyl)-3-oxo-propionic acid ethyl ester

4-(methanesulfonyl)acetophenone