42840-02-8

Basic information

• Product Name: Benzoyl chloride, 2-[[(4-methylphenyl)sulfonyl]amino]-
• CAS NO: 42840-02-8
• Molecular Formula: C14H12ClNO3S
• Molecular Weight: 309.773
• Mol File: 42840-02-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-[[(4-methylphenyl)sulfonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-[[(4-methylphenyl)sulfonyl]amino]-(42840-02-8)
• EPA Substance Registry System: Benzoyl chloride, 2-[[(4-methylphenyl)sulfonyl]amino]-(42840-02-8)

Safety Data

• Hazardous Substances Data: 42840-02-8(Hazardous Substances Data)

Upstream product

• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 118-92-3 anthranilic acid 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 98-88-4 benzoyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1140-17-6 2-amino-4'-bromobenzophenone 
• 500315-91-3 toluene-4-sulfonic acid-[2-(3,4-dimethyl-benzoyl)-anilide] 
• 854636-88-7 toluene-4-sulfonic acid-[2-(4-methoxy-2,3-dimethyl-benzoyl)-anilide] 
• 1816-96-2 (2,5-dimethylphenyl)tolylsulfone 
• 1816-95-1 toluene-4-sulfonic acid-[2-(2,5-dimethyl-benzoyl)-anilide] 
• 861531-46-6 toluene-4-sulfonic acid-[2-(2,3,4-trimethoxy-benzoyl)-anilide] 
• 857005-22-2 toluene-4-sulfonic acid-[2-(2,4-dimethyl-benzoyl)-anilide] 
• 854636-80-9 toluene-4-sulfonic acid-[2-(4-methoxy-2,5-dimethyl-benzoyl)-anilide] 
• 640-57-3 phenyltolylsulfone 
• 39031-30-6 5,11-bis-(toluene-4-sulfonyl)-5H,11H-dibenzo[b,f][1,5]diazocine-6,12-dione 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 75127-50-3 N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide 
• 370851-82-4 2-(4-bromobenzoyl)-1-(4-methylphenylsulfonamido)benzene 

Relevant articles and documents

Metal-free C-H Activation over Graphene Oxide toward Direct Syntheses of Structurally Different Amines and Amides in Water

Unprecedented metal-free synthesis of a variety of amines and amides is reported via amination of C(sp3)-H and C(sp2)-H bonds. The strategy involves graphene-oxide/I2-catalyzed nitrene insertion using PhINTs as a nitrene (NT) source in water at room temperature. A wide range of structurally different substrates, viz., cyclohexane, cyclic ethers, arenes, alkyl aromatic systems, and aldehydes/ketones, having an α-phenyl ring have been employed successfully to afford the corresponding nitrene insertion product in good yield, albeit low in few cases. The envisaged method has superiority over others in terms of its operational simplicity, metal-free catalysis, use of water as a solvent, ambient reaction conditions, and reusability of the catalyst.

Synthesis and Caco-2 cell permeability of N-substituted anthranilamide esters as ADP inhibitor in platelets

Twelve N-substituted anthranilamide esters (1-5, 8, 9, 12, 13, and 15-17) were synthesized and evaluated for their ability to inhibit the in vitro aggregation by washed human platelets induced by adenosine 5′-diphosphate (10 μM). The antiplatelet activity of DL-n-butyl 5-hydroxy-N-(2-phenoxypropionyl)anthranilate (9, IC50 = 10.5 μM) was most active among the tested compounds and ethyl ester 8 (IC50 = 11.2 μM) showed the second most activity. DL-Ethyl and DL-n-butyl 5-(p-toluenesulfonyloxy)-N-(2-phenoxypropionyl)anthranilate (12, IC50 = 13.1 μM and 13, IC50 = 14.0 μM), DL-methyl N-(2-phenoxybutyryl)anthranilate (2, IC50 = 12.7 μM), DL-N-(2-phenoxypropionyl)anthranilic acid (5, IC50 = 13.7 μM) displayed lower antiplatelet activity than 8 and 9. Compound 5 was more active than methyl ester prodrug 1. n-Butyl 5-hydroxy-N-(4′-acetoxybenzoyl)anthranilate (15, IC50 = 28.3 μM) showed moderate activity. Compounds 1 (IC50 = 42.8 μM), 4 (IC50 = 56.7 μM), 16 (IC50 = 51.0 μM), and 17 (IC50 = 49.8 μM) exhibited low antiplatelet activity. Methyl N-phenoxyacetylanthranilate (3, IC50 = 78.0 μM) showed the lowest antiplatelet activity. The compounds with branched alkyl chain (2 and 5) were more active than compounds with straight chain (3 and 4). The apparent permeability coefficient (Papp, cm/s) values of compounds 2 and 9 were determined as 45.34 ± 4.67 and 33.17 ± 5.15 × 10-6 cm/s by Caco-2 cell permeability assay.

Synthesis of photochromic dithienylethenes having quinoline and Triazolo[4,3-a]quinoline bridges

Convenient synthetic approaches to new photochromic dithienylethenes with quinoline and triazolo[4,3-a]quinoline bridging fragments have been developed.