4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

Base Information

Chemical Name:4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide
CAS No.:220032-14-4
Molecular Formula:C₁₉H₂₉ClN₄O₂
Molecular Weight:380.918
Hs Code.:

Synonyms:4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

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Chemical Property of 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

Chemical Property:

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Technology Process of 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

There total 5 articles about 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220032-18-8
4-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid benzyl ester

: 220032-14-4
4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

Guidance literature:: With methanesulfonic acid; methoxybenzene; In chloroform; for 3h; Heating;
DOI:10.1016/S0960-894X(02)00060-4

Reference yield:

: 498-94-2
isonipecotic acid

: 220032-14-4
4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / 15 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 1 h / Heating

3: Et₃N / 4 h / 20 °C

4: 96 percent / BH₃ / tetrahydrofuran / 13 h / 20 °C

5: 30 percent aq. HCl / ethanol / 1 h / 20 °C

6: EDC / CH₂Cl₂ / 3 h / 20 °C

7: MeSO₃H; anisole / CHCl₃ / 3 h / Heating

With hydrogenchloride; thionyl chloride; methanesulfonic acid; borane; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1016/S0960-894X(02)00060-4

Reference yield:

: 247918-53-2
4-amino-1-(1-benzyloxycarbonyl-4-piperidinylmethyl)piperidine

: 220032-14-4
4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC / CH₂Cl₂ / 3 h / 20 °C

2: MeSO₃H; anisole / CHCl₃ / 3 h / Heating

With methanesulfonic acid; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; chloroform;
DOI:10.1016/S0960-894X(02)00060-4