247918-53-2

Upstream product

• 220031-89-0 1-[(1-benzyloxycarbonyl)-4-piperidinylmethyl]-4-(t-butoxycarbonylamino)piperidine 
• 220031-94-7 1-(1-benzyloxycarbonyl-4-piperidinylcarbonyl)-4-(t-butoxycarbonylamino)piperidine 
• 501-53-1 benzyl chloroformate 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 

Downstream Products

• 247918-68-9 4-acetylamino-N-[1-(1-benzyloxycarbonyl-4-piperidinylmethyl)-4-piperidinyl]-5-chloro-2,3-dihydrobenzo [b]furan-7-carboxamide 
• 220032-14-4 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide 
• 220032-18-8 4-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents.

A series of novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides was prepared and its compounds were evaluated for their binding to 5-HT(4) receptors and effects on gastrointestinal motility in conscious dogs. 4-Amino-N-[1-[1-(4-aminobu

2-ALKOXY-6-AMINO-5-HALOGENO-N-(1-SUBSTITUTED-4-PIPERIDINYL)PYRIDINE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a compound exhibiting high affinity for serotonin 4 receptor and useful as a digestive tract motion promoting agent or digestive tract function ameliorating agent. SOLUTION: The compound is represented by the formula(I), or an acid addition salt thereof and an intermediate thereof are provided. In formula(I), R1 is a halogen atom; R2 is H or a lower alkyl; R3 is H, a lower alkyl or the like; R4 is a lower alkyl; A is a group represented by the formula: Z-N(Q1)(Q2) or CO-R5, wherein Z is CO, CS or the like; Q1 and Q2 are each H, a lower alkyl or the like, or joined together with the nitrogen atom to which Q1 and Q2 are bound to form a pyrrolidine ring, piperidine ring or the like; and R5 is H, a lower alkyl, lower alkoxy, lower alkoxycarbonyl or the like.

1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds

Compound of the formula (I): STR1wherein Ar is a group of the following formula (Ar-1) or (Ar-2): STR2A is a group of the formula:--Z--N(Q 1)(Q 2), --CO--R 7or--(CH 2)p--CH(R 8)--COR 9,or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, a pharmaceutical composition containing the same, and intermediates therefor. The compounds of the present invention show a potent affinity for 5-HT 4 receptors, and they are useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent.