4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Base Information

• Chemical Name: 4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• CAS No.: 220031-89-0
• Molecular Formula: C24H37N3O4
• Molecular Weight: 431.56800
• Mol file: 220031-89-0.mol

Synonyms:1-(1-benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine;Disiloxane,1,1,3,3-tetramethyl-1-(1-phenylethoxy);1-(1'-benzylethoxy)-1,1,3,3-tetramethyldisiloxane;2-phenyl-3,5-dioxa-4,4',6,6'-tetramethyl-4,6-disilahexane;1-(1'-phenylethoxy)-1,1,3,3-tetramethyldisiloxane;

Chemical Property of 4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Chemical Property:

• PSA: 71.11000
• LogP: 4.29100

Purity/Quality:

97% ^*data from raw suppliers

4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

There total 4 articles about 4-(4-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-1-YLMETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(1-benzyloxycarbonyl-4-piperidinylcarbonyl)-4-(t-butoxycarbonylamino)piperidine (220031-94-7) → 1-[(1-benzyloxycarbonyl)-4-piperidinylmethyl]-4-(t-butoxycarbonylamino)piperidine (220031-89-0)

Guidance literature:

With borane; In tetrahydrofuran; at 20 ℃; for 13h;

DOI:10.1016/S0960-894X(02)00060-4

Reference yield:

isonipecotic acid (498-94-2) → 1-[(1-benzyloxycarbonyl)-4-piperidinylmethyl]-4-(t-butoxycarbonylamino)piperidine (220031-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / 15 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 1 h / Heating

3: Et₃N / 4 h / 20 °C

4: 96 percent / BH₃ / tetrahydrofuran / 13 h / 20 °C

With thionyl chloride; borane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(02)00060-4

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 1-[(1-benzyloxycarbonyl)-4-piperidinylmethyl]-4-(t-butoxycarbonylamino)piperidine (220031-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / 15 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 1 h / Heating

3: Et₃N / 4 h / 20 °C

4: 96 percent / BH₃ / tetrahydrofuran / 13 h / 20 °C

With thionyl chloride; borane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(02)00060-4

upstream raw materials:

1-(1-benzyloxycarbonyl-4-piperidinylcarbonyl)-4-(t-butoxycarbonylamino)piperidine

isonipecotic acid

benzyl chloroformate

Downstream raw materials:

4-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-piperidin-1-ylmethyl]-piperidine-1-carboxylic acid benzyl ester

4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide

4-amino-1-(1-benzyloxycarbonyl-4-piperidinylmethyl)piperidine