(2R,4S,5S)-1--2-furanyl>thymine

Base Information

Chemical Name:(2R,4S,5S)-1--2-furanyl>thymine
CAS No.:132178-47-3
Molecular Formula:C₁₈H₂₃N₂O₇PSe
Molecular Weight:489.324
Hs Code.:

(2R,4S,5S)-1-<tetrahydro-4-(phenylselenyl)-5-<(dimethoxyphosphinyl)methoxy>-2-furanyl>thymine

Synonyms:(2R,4S,5S)-1--2-furanyl>thymine

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Chemical Property of (2R,4S,5S)-1--2-furanyl>thymine

Chemical Property:

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Technology Process of (2R,4S,5S)-1--2-furanyl>thymine

There total 4 articles about (2R,4S,5S)-1--2-furanyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5707-04-0
Phenylselenyl chloride

: 24630-67-9
hydroxymethyl-phosphonic acid dimethyl ester

: 37076-62-3
(2'R)-1-(2,3-dihydrofuran-2-yl)thymine

: 132178-47-3
(2R,4S,5S)-1--2-furanyl>thymine

Guidance literature:: Phenylselenyl chloride; (2'R)-1-(2,3-dihydrofuran-2-yl)thymine; In dichloromethane; at -78 ℃;

hydroxymethyl-phosphonic acid dimethyl ester; With silver perchlorate; In dichloromethane; Further stages.;
DOI:10.1016/j.bmcl.2007.10.038

Reference yield:

: 24630-67-9
hydroxymethyl-phosphonic acid dimethyl ester

: 132178-45-1,132178-46-2
1-((R)-5-Chloro-4-phenylselanyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 132178-47-3
(2R,4S,5S)-1--2-furanyl>thymine

Guidance literature:: With silver perchlorate; In dichloromethane; acetonitrile; Yield given; -70 deg C, 3 min, then warming up to 0 deg C;
DOI:10.1021/jo00008a013

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 132178-47-3
(2R,4S,5S)-1--2-furanyl>thymine

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / -70 °C

2: AgClO₄ / acetonitrile; CH₂Cl₂ / -70 deg C, 3 min, then warming up to 0 deg C

With silver perchlorate; In dichloromethane; acetonitrile;
DOI:10.1021/jo00008a013