(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

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Chemical Name:(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one
CAS No.:1055040-15-7
Molecular Formula:C₄₂H₆₅NO₁₀Si
Molecular Weight:772.064
Hs Code.:

Synonyms:(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

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Chemical Property of (2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

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Technology Process of (2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

There total 2 articles about (2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 3-propylmagnesium chloride

: 213197-97-8
1,4-dihydro-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-pyridin-4(1H)-one

: 1055040-15-7
(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

Guidance literature:: 1,4-dihydro-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-pyridin-4(1H)-one; With triisopropylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.5h;

3-propylmagnesium chloride; With 2,6-dimethylpyridine; In tetrahydrofuran; dichloromethane; at 20 ℃;
DOI:10.1002/ejoc.200400169

Reference yield:

: 27248-04-0
4-((trimethylsilyl)oxy)pyridine

: 1055040-15-7
(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / TiCl₄ / 1,2-dichloro-ethane / 1 h / Heating

2.1: TIPSOTf / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 66 percent / 2,6-lutidine / CH₂Cl₂; tetrahydrofuran / 20 °C

With triisopropylsilyl trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/ejoc.200400169

Reference yield: 81.0%

: 75-03-6
ethyl iodide

: 1055040-15-7
(2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

: (2S,3S)-2-{3-[dimethyl(phenyl)silyl]propyl}-3-ethyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one

Guidance literature:: (2S)-2,3-dihydro-2-{3-[dimethyl(phenyl)silyl]propyl}-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)pyridine-4(1H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

ethyl iodide; In tetrahydrofuran; at -10 ℃; for 12h;
DOI:10.1002/ejoc.200400169