2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

Base Information

Chemical Name:2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine
CAS No.:1323916-90-0
Molecular Formula:C₂₅H₁₅ClFN₃
Molecular Weight:411.866
Hs Code.:

Synonyms:2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

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Chemical Property of 2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

Chemical Property:

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Technology Process of 2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

There total 4 articles about 2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323919-45-4
2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid

: 98420-98-5
4-bromo-2-phenyl pyridine

: 1323916-90-0
2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1323916-90-0
2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere

With potassium acetate; sodium hydrogencarbonate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 59514-89-5
2,4-dichloro-[1,8]naphthyridine

: 1323916-90-0
2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere

With potassium acetate; sodium hydrogencarbonate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;