59514-89-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-Dichloro-1,8-naphthyridine is used as a key intermediate in the synthesis of pharmaceuticals for its unique chemical structure and reactivity. It contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2,4-Dichloro-1,8-naphthyridine is utilized as a precursor in the creation of various agrochemicals, enhancing crop protection and management strategies.
Used in Antimicrobial and Antifungal Applications:
Leveraging its antimicrobial and antifungal properties, 2,4-Dichloro-1,8-naphthyridine is employed as an active ingredient in products designed to combat microbial infections and fungal growth, particularly in medical and industrial settings.
Used in Research and Development:
2,4-Dichloro-1,8-naphthyridine serves as a valuable building block in the production of various organic compounds, making it a common component in research and development processes aimed at discovering and improving chemical compounds and their applications.

InChI:InChI=1/C8H4Cl2N2/c9-6-4-7(10)12-8-5(6)2-1-3-11-8/h1-4H

Upstream product

• 219775-95-8 1-benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one 
• 504-29-0 2-aminopyridine 
• 1663-67-8 malonoyl dichloride 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 59514-86-2 [1,8]naphthyridine-2,4-diol 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 

Downstream Products

• 59514-93-1 4-chloro-1,8-naphthyridin-2-one 
• 13623-87-5 1,2,3,4-tetrahydro-1,8-naphthyridine 
• 1353968-26-9 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-hydroxy-ethyl)-2H-[2,7]naphthyridin-1-one 
• 1353968-39-4 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one 
• 1353968-43-0 2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-morpholin-4-yl-ethoxy)-[2,7]naphthyridin-4-yl]-[1,8]naphthyridine 
• 1353968-55-4 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine 
• 1353968-79-2 N'-{5-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-isoquinolin-8-yl}-N,N-diethyl-ethane-1,2-diamine 
• 1353969-27-3 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-1-(2-morpholin-4-yl-ethyl)-1H-[1,7]naphthyridin-2-one 
• 1353969-32-0 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethoxy)-[1,7]naphthyridine 
• 1353967-13-1 2-(2-fluoro-5-trifluoromethyl-phenyl)-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)-[1,8]naphthyridine 
• 1353969-93-3 2-(5-chloro-2-fluoro-phenyl)-4-(2-oxy-isoquinolin-5-yl)-[1,8]naphthyridine 
• 1353969-96-6 2-(5-chloro-2-fluoro-phenyl)-4-(6-oxy-furo[2,3-c]pyridin-3-yl)-[1,8]naphthyridine 
• 1353967-23-3 2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-methoxy-ethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-[1,8]naphthyridine 
• 1353967-14-2 2-(5-chloro-2-fluoro-phenyl)-4-isoquinolin-5-yl-[1,8]naphthyridine 

Relevant academic research and scientific papers

INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

4-Aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome sequencing of mutants raised against AQs, identified decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) as the primary target responsible for the antitubercular activity. Mass spectrometry and enzyme kinetic studies indicated that AQs are noncovalent, reversible inhibitors of DprE1 with slow on rates and long residence times of ～100 min on the enzyme. In general, AQs have excellent leadlike properties and good in vitro secondary pharmacology profile. Although the scaffold started off as a single active compound with moderate potency from the whole cell screen, structure-activity relationship optimization of the scaffold led to compounds with potent DprE1 inhibition (IC50 10 nM) along with potent cellular activity (MIC = 60 nM) against Mtb.

2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particu

2,4- DIARYL-SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases playsa role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors

4-thio substituted quinoline and naphthyridine compounds

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.

4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.