ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

Base Information

Chemical Name:ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate
CAS No.:935253-38-6
Molecular Formula:C₃₆H₄₃NO₃
Molecular Weight:537.742
Hs Code.:

Synonyms:ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

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Chemical Property of ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

Chemical Property:

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Technology Process of ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

There total 12 articles about ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

: 14469-83-1
(5-bromopentyl)benzene

: 934753-52-3
ethyl E-6-[2-(4-cyanophenyl)ethyl]-8-(2-hydroxyphenyl)oct-7-enoate

: 935253-38-6
ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;

Reference yield:

: 1-(2-bromoethyl)-4-hydroxymethylbenzene

: 935253-38-6
ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: formic acid; hydroxylamine hydrochloride / 2 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

5.1: borane-THF / tetrahydrofuran / -10 - 0 °C

6.1: pyridinium chlorochromate / dichloromethane / 20 °C

7.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

8.1: potassium carbonate / acetonitrile / Reflux

With n-butyllithium; formic acid; borane-THF; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 935253-38-6
ethyl (7E)-6-[2-(4-cyanophenyl)ethyl]-8-{2-[(5-phenylpentyl)oxy]phenyl}oct-7-enoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1,4-dioxane / 5 - 40 °C

1.2: 110 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 0 - 20 °C

3.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

4.1: borane-THF / tetrahydrofuran / -10 - 0 °C

5.1: pyridinium chlorochromate / dichloromethane / 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

7.1: potassium carbonate / acetonitrile / Reflux

With n-butyllithium; formic acid; borane-THF; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;