N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Base Information

Chemical Name:N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide
CAS No.:167837-47-0
Molecular Formula:C₃₄H₃₂Cl₂N₂O₄Si
Molecular Weight:631.631
Hs Code.:

Synonyms:N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

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Chemical Property of N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

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Technology Process of N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

There total 10 articles about N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 167837-46-9
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

: 167837-47-0
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In methanol; dichloromethane; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112948

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 167837-47-0
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/jm980300f

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 167837-47-0
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

With 1H-imidazole; iron(III) chloride; sodium hydride; hydrazine hydrate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f