(R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

• Chemical Name: (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
• CAS No.: 1613721-08-6
• Molecular Formula: C₂₈H₂₉N₅O₂
• Molecular Weight: 467.571
• Mol file: 1613721-08-6.mol

Synonyms:(R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Chemical Property of (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 6 articles about (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(R)-6-amino-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one (1613721-07-5) + methanesulfonic acid 1-benzhydryl-3-methylazetidin-3-yl ester (133891-87-9) → (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one (1613721-08-6)

Guidance literature:

With potassium carbonate; In isopropyl alcohol; at 80 - 90 ℃; for 16h;

DOI:10.1021/jm5013006

Reference yield:

1-benzhydryl-3-methylazetidin-3-ol (40320-63-6) → (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one (1613721-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 °C

2: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

With potassium carbonate; triethylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jm5013006

Reference yield:

N-benzhydryl 3-azetidinone (40320-60-3) → (R)-6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one (1613721-08-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 2.17 h / 0 - 20 °C

2: triethylamine / dichloromethane / 3 h / 0 °C

3: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm5013006

upstream raw materials:

1-benzhydryl-3-methylazetidin-3-ol

N-benzhydryl 3-azetidinone

(R)-6-amino-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

methanesulfonic acid 1-benzhydryl-3-methylazetidin-3-yl ester

Downstream raw materials:

6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid