C₃₅H₅₆N₂O₉Si₂

Base Information

• Chemical Name: C₃₅H₅₆N₂O₉Si₂
• CAS No.: 1197388-84-3
• Molecular Formula: C₃₅H₅₆N₂O₉Si₂
• Molecular Weight: 705.009
• Mol file: 1197388-84-3.mol

Synonyms:C₃₅H₅₆N₂O₉Si₂

Chemical Property of C₃₅H₅₆N₂O₉Si₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₃₅H₅₆N₂O₉Si₂

There total 2 articles about C₃₅H₅₆N₂O₉Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2',3'-O-bis(tert-butyldimethylsilyl)-3-N-(p-methoxybenzyl)uridine-5'-aldehyde (137233-53-5) + (2-(tert-butoxy)-2-oxoethyl)dimethylsulfonium bromide → C35H56N2O9Si2 (1197388-84-3)

Guidance literature:

(2-(tert-butoxy)-2-oxoethyl)dimethylsulfonium bromide; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h; Molecular sieve;

2',3'-O-bis(tert-butyldimethylsilyl)-3-N-(p-methoxybenzyl)uridine-5'-aldehyde; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1055/s-0029-1217742

Reference yield:

tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) + C31H48N2O9Si2 → C35H56N2O9Si2 (1197388-84-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 96h;

DOI:10.1055/s-0029-1217742

Reference yield: 64.0%

C17H27N3O3*ClH (1197388-81-0) + C35H56N2O9Si2 (1197388-84-3) → 2-[3-(2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester (473710-39-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; at 65 ℃; for 144h;

DOI:10.1055/s-0029-1217742

upstream raw materials:

tert-Butyl 2,2,2-trichloroacetimidate

2',3'-O-bis(tert-butyldimethylsilyl)-3-N-(p-methoxybenzyl)uridine-5'-aldehyde

Downstream raw materials:

2-[3-(2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester