N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

Base Information

Chemical Name:N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine
CAS No.:354806-78-3
Molecular Formula:C₁₉H₁₅F₄N₃O₂S
Molecular Weight:425.407
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

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Chemical Property of N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

Chemical Property:

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Technology Process of N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

There total 4 articles about N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 342651-55-2
2-(methylsulfonyl)-4-[4-(methylsulfonyl)-phenyl]-6-(trifluoromethyl)pyrimidine

: 140-75-0
para-fluorobenzylamine

: 354806-78-3
N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: In acetonitrile; at 140 ℃; Sealed tube;
DOI:10.1039/c3ob41935e

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 354806-78-3
N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol; diethyl ether / 18 h / 20 °C

2: acetic acid; sodium acetate / 6 h / Reflux

3: Oxone / water; methanol / 18 h / 20 °C

4: acetonitrile / 140 °C / Sealed tube

With Oxone; sodium methylate; sodium acetate; acetic acid; In methanol; diethyl ether; water; acetonitrile; 1: |Claisen Condensation;
DOI:10.1039/c3ob41935e

Reference yield:

: 134731-32-1
1-[4-(methylthio)phenyl]-4,4,4-trifluorobutane-1,3-dione

: 354806-78-3
N-(4-fluorobenzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium acetate / 6 h / Reflux

2: Oxone / water; methanol / 18 h / 20 °C

3: acetonitrile / 140 °C / Sealed tube

With Oxone; sodium acetate; acetic acid; In methanol; water; acetonitrile;
DOI:10.1039/c3ob41935e