methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate

Base Information

• Chemical Name: methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate
• CAS No.: 197235-08-8
• Molecular Formula: C₁₆H₁₆ClNO₄
• Molecular Weight: 321.76
• Mol file: 197235-08-8.mol

Synonyms:methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate

Chemical Property of methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate

There total 3 articles about methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propynoic acid methyl ester (922-67-8) + 5-chloro-3-(3,4-dimethoxyphenyl)-6-methyl-2H-1,4-oxazin-2-one (182552-86-9) → methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate (197235-08-8)

Guidance literature:

In toluene; at 80 ℃;

DOI:10.1016/S0040-4020(97)00791-6

Reference yield:

1,2-dimethoxybenzene (91-16-7) → methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate (197235-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂ / 20 °C

2: 80 °C

With aluminium trichloride; In dichloromethane; 1: Substitution / 2: Cycloaddition;

DOI:10.1016/S0040-4039(99)01943-7

Reference yield:

propynoic acid methyl ester (922-67-8) + 5-chloro-3-(3,4-dimethoxyphenyl)-6-methyl-2H-1,4-oxazin-2-one (182552-86-9) → methyl 6-chloro-2-(3,4-dimethoxyphenyl)-5-methyl-3-pyridinecarboxylate (197235-08-8) + 2-chloro-6-(3,4-dimethoxy-phenyl)-3-methyl-isonicotinic acid methyl ester

Guidance literature:

at 80 ℃;

DOI:10.1016/S0040-4039(99)01943-7

upstream raw materials:

propynoic acid methyl ester

5-chloro-3-(3,4-dimethoxyphenyl)-6-methyl-2H-1,4-oxazin-2-one

1,2-dimethoxybenzene