(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

Base Information

Chemical Name:(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide
CAS No.:223769-23-1
Molecular Formula:C₁₈H₂₃F₃N₂O₃
Molecular Weight:372.387
Hs Code.:

Synonyms:(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

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Chemical Property of (S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

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Technology Process of (S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

There total 3 articles about (S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 223769-22-0
tert?butyl(S)?2?((4?(trifluoromethyl)phenyl)carbamoyl)pyrrolidine?1?carboxylate

: 74-88-4
methyl iodide

: 223769-23-1
(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo981808t

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 223769-23-1
(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / N-methylmorpholine, ethyl chloroformate / ethyl acetate / 1 h / -15 °C

2: 92 percent / NaH / tetrahydrofuran / 12 h / Ambient temperature

With 4-methyl-morpholine; chloroformic acid ethyl ester; sodium hydride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo981808t

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 223769-23-1
(S)-1-(tert-butoxycarbonyl)-N-methyl-N-(4-trifluoromethylphenyl)-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / N-methylmorpholine, ethyl chloroformate / ethyl acetate / 1 h / -15 °C

2: 92 percent / NaH / tetrahydrofuran / 12 h / Ambient temperature

With 4-methyl-morpholine; chloroformic acid ethyl ester; sodium hydride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo981808t