C₇₁H₉₀O₁₂S

Base Information

• Chemical Name: C₇₁H₉₀O₁₂S
• CAS No.: 342902-05-0
• Molecular Formula: C₇₁H₉₀O₁₂S
• Molecular Weight: 1167.55
• Mol file: 342902-05-0.mol

Synonyms:C₇₁H₉₀O₁₂S

Chemical Property of C₇₁H₉₀O₁₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₁H₉₀O₁₂S

There total 56 articles about C₇₁H₉₀O₁₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanethiol (75-08-1) + C73H94O14 → C71H90O12S (342902-05-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

Reference yield:

benzyl bromide (100-39-0) → C71H90O12S (342902-05-0)

Guidance literature:

Multi-step reaction with 33 steps

1.1: n-Bu₂SnO / benzene / Heating

1.2: CsF / dimethylformamide / 20 °C

2.1: NaH; CS₂; MeI / tetrahydrofuran / 20 °C

2.2: n-Bu₃SnH; AIBN / benzene / Heating

3.1: conc. HCl / CHCl₃ / 20 °C

3.2: 46 percent / camphorsulfonic acid / CH₂Cl₂ / 20 °C

4.1: 97 percent / N-methylmorpholine / CH₂Cl₂ / 20 °C

5.1: 98 percent / MeI; NaHCO₃ / acetonitrile; H₂O / 20 °C

6.1: SmI₂; HMPA / methanol; tetrahydrofuran / 0 °C

7.1: LiAlH₄ / tetrahydrofuran / 20 °C

8.1: 84 percent / NaH / dimethylformamide / 20 °C

9.1: 89 percent / camphorsulfonic acid / methanol / 20 °C

10.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

11.1: camphorsulfonic acid / methanol / 0 °C

12.1: I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

13.1: t-BuOK / tetrahydrofuran / 20 °C

14.1: 9-BBN / tetrahydrofuran / 20 °C

14.2: 85 percent / 1 M aq. NaHCO₃ / [Pd(PPh₃)4] / dimethylformamide / 50 °C

15.1: 3,3-dimethyldioxirane / acetone / -78 - -20 °C

15.2: 60 percent / Et₃SiH; BH₃*THF / CH₂Cl₂ / -20 °C

16.1: 80 percent / t-BuOK; n-Bu₄NI / tetrahydrofuran / 20 °C

17.1: 97 percent / TBAF / tetrahydrofuran / 20 °C

18.1: 100 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

19.1: DDQ / CH₂Cl₂; H₂O; various solvent(s) / 20 °C

20.1: Zn(OTf)2 / CH₂Cl₂ / 20 °C

21.1: DMAP; Et₃N / CH₂Cl₂ / 0 °C

22.1: 96 percent / mCPBA / CH₂Cl₂ / 20 °C

23.1: CH₂Cl₂ / -78 - 0 °C

23.2: 83 percent / K₂CO₃ / methanol / 20 °C

24.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

25.1: camphorsulfonic acid / methanol; CH₂Cl₂ / 0 °C

26.1: 94 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

27.1: 87 percent / t-BuOK / tetrahydrofuran / 0 °C

28.1: 9-BBN / tetrahydrofuran / 20 °C

28.2: 71 percent / Cs₂CO₃ / [Pd(PPh₃)4] / dimethylformamide / 0 °C

29.1: BH₃*THF / tetrahydrofuran / 20 °C

29.2: 81 percent / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 20 °C

30.1: camphorsulfonic acid / CH₂Cl₂ / 20 °C

31.1: TBAF / tetrahydrofuran / 20 °C

32.1: tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

33.1: Zn(OTf)2 / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; carbon disulfide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; samarium diiodide; tetrapropylammonium perruthennate; borane-THF; 4 A molecular sieve; camphor-10-sulfonic acid; potassium tert-butylate; tetrabutyl ammonium fluoride; iodine; 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; sodium hydride; di(n-butyl)tin oxide; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 14.2: B-alkyl Suzuki coupling reaction / 28.2: B-alkyl Suzuki coupling reaction;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

Reference yield:

(2R,4aR,6S,7S,8R,8aR)-8-Benzyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol (2774-19-8,14419-69-3,15887-67-9,23392-28-1,57539-08-9,61277-63-2,74410-51-8,76419-48-2,80734-73-2,86363-44-2,89301-79-1,94061-92-4,94062-87-0,108739-92-0,129706-93-0,143005-12-3,65877-21-6) → C71H90O12S (342902-05-0)

Guidance literature:

Multi-step reaction with 32 steps

1.1: NaH; CS₂; MeI / tetrahydrofuran / 20 °C

1.2: n-Bu₃SnH; AIBN / benzene / Heating

2.1: conc. HCl / CHCl₃ / 20 °C

2.2: 46 percent / camphorsulfonic acid / CH₂Cl₂ / 20 °C

3.1: 97 percent / N-methylmorpholine / CH₂Cl₂ / 20 °C

4.1: 98 percent / MeI; NaHCO₃ / acetonitrile; H₂O / 20 °C

5.1: SmI₂; HMPA / methanol; tetrahydrofuran / 0 °C

6.1: LiAlH₄ / tetrahydrofuran / 20 °C

7.1: 84 percent / NaH / dimethylformamide / 20 °C

8.1: 89 percent / camphorsulfonic acid / methanol / 20 °C

9.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

10.1: camphorsulfonic acid / methanol / 0 °C

11.1: I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

12.1: t-BuOK / tetrahydrofuran / 20 °C

13.1: 9-BBN / tetrahydrofuran / 20 °C

13.2: 85 percent / 1 M aq. NaHCO₃ / [Pd(PPh₃)4] / dimethylformamide / 50 °C

14.1: 3,3-dimethyldioxirane / acetone / -78 - -20 °C

14.2: 60 percent / Et₃SiH; BH₃*THF / CH₂Cl₂ / -20 °C

15.1: 80 percent / t-BuOK; n-Bu₄NI / tetrahydrofuran / 20 °C

16.1: 97 percent / TBAF / tetrahydrofuran / 20 °C

17.1: 100 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

18.1: DDQ / CH₂Cl₂; H₂O; various solvent(s) / 20 °C

19.1: Zn(OTf)2 / CH₂Cl₂ / 20 °C

20.1: DMAP; Et₃N / CH₂Cl₂ / 0 °C

21.1: 96 percent / mCPBA / CH₂Cl₂ / 20 °C

22.1: CH₂Cl₂ / -78 - 0 °C

22.2: 83 percent / K₂CO₃ / methanol / 20 °C

23.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

24.1: camphorsulfonic acid / methanol; CH₂Cl₂ / 0 °C

25.1: 94 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

26.1: 87 percent / t-BuOK / tetrahydrofuran / 0 °C

27.1: 9-BBN / tetrahydrofuran / 20 °C

27.2: 71 percent / Cs₂CO₃ / [Pd(PPh₃)4] / dimethylformamide / 0 °C

28.1: BH₃*THF / tetrahydrofuran / 20 °C

28.2: 81 percent / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 20 °C

29.1: camphorsulfonic acid / CH₂Cl₂ / 20 °C

30.1: TBAF / tetrahydrofuran / 20 °C

31.1: tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

32.1: Zn(OTf)2 / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; carbon disulfide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; samarium diiodide; tetrapropylammonium perruthennate; borane-THF; 4 A molecular sieve; camphor-10-sulfonic acid; potassium tert-butylate; tetrabutyl ammonium fluoride; iodine; 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; sodium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; acetonitrile; 13.2: B-alkyl Suzuki coupling reaction / 27.2: B-alkyl Suzuki coupling reaction;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

upstream raw materials:

ethanethiol

benzyl bromide

(2R,4aR,6S,7S,8R,8aR)-8-Benzyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

Methyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-α-D-arabino-hexopyranoside