{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

Base Information

Chemical Name:{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester
CAS No.:349609-06-9
Molecular Formula:C₄₀H₄₅N₃O₉
Molecular Weight:711.812
Hs Code.:

Synonyms:{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

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Chemical Property of {[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

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Technology Process of {[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

There total 8 articles about {[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 160617-43-6
N-Fmoc-sarcosine acid chloride

: 349609-17-2
N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

: 349609-06-9
{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane;
DOI:10.1002/1521-3773(20010417)40:8<1463::AID-ANIE1463>3.0.CO;2-8

Reference yield:

: 62717-78-6,141303-38-0
2-(2-methoxyphenyl)oxirane

: 349609-06-9
{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. NaN₃ / acetone / 3 h / Heating

2.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

2.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

3.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

4.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

5.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

6.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

7.1: 10.0 g / DMAP; pyridine / CH₂Cl₂; dimethylformamide; hexane / 0.75 h / 0 °C

With pyridine; dmap; lithium hydroxide; sodium azide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja0174027

Reference yield:

: 2-azido-2-(2-methoxy-phenyl)-ethanol

: 349609-06-9
{[[2-benzyloxy-1-(2-methoxy-3-nitro-phenyl)-ethyl]-(2,2-diethoxyethyl)-carbamoyl]-methyl}-methyl-carbamic acid 9H-fluoren-9-yl-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

1.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

2.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

3.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

4.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

5.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

6.1: 10.0 g / DMAP; pyridine / CH₂Cl₂; dimethylformamide; hexane / 0.75 h / 0 °C

With pyridine; dmap; lithium hydroxide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja0174027