(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

Base Information

Chemical Name:(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester
CAS No.:1408447-80-2
Molecular Formula:C₂₆H₄₁NO₇
Molecular Weight:479.614
Hs Code.:

Synonyms:(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

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Chemical Property of (2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

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Technology Process of (2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

There total 11 articles about (2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407507-20-3
Di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

: 1408447-80-2
(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

: 1408447-83-5
(2S,5S)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

Guidance literature:: With dmap; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1408447-80-2
(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

: 1408447-83-5
(2S,5S)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane; pyridine / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

4.1: dmap / 1,4-dioxane / 100 °C

With pyridine; dmap; hydrogen; sodium hydride; Dess-Martin periodane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1408447-80-2
(2S,5R)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

: 1408447-83-5
(2S,5S)-2-tert.-butoxycarbonylamino-5-(4-hydroxy-benzyl)-hexanedioic acid di-tert.-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

4.1: dmap / 1,4-dioxane / 100 °C

With dmap; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; mineral oil;