Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

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Chemical Name:Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate
CAS No.:1241898-23-6
Molecular Formula:C₂₀H₂₃N₇O₅
Molecular Weight:441.447
Hs Code.:

Synonyms:Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

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Chemical Property of Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

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Technology Process of Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

There total 4 articles about Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-22-5
benzyl 4-[5-(1H-tetrazol-5-yl)isoxazol-3-yl]piperazine-1-carboxylate

: 105-36-2
ethyl bromoacetate

: 1241898-23-6
Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

: benzyl 4-{5-[1-(2-ethoxy-2-oxoethyl)-1H-tetrazol-5-yl]isoxazol-3-yl}piperazine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 80 ℃; for 1h;

Reference yield:

: 1241898-19-0
benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

: 1241898-23-6
Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

: benzyl 4-{5-[1-(2-ethoxy-2-oxoethyl)-1H-tetrazol-5-yl]isoxazol-3-yl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate; iodine / toluene / 12 h / Reflux

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 1 h / 100 °C

4: triethylamine / tetrahydrofuran / 1 h / 80 °C

With sodium azide; iodine; sodium acetate; ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1241898-20-3
benzyl 4-[5-(aminocarbonyl)isoxazol-3-yl]piperazine-1-carboxylate

: 1241898-23-6
Benzyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl] isoxazol-3-yl}piperazine-1-carboxylate

: benzyl 4-{5-[1-(2-ethoxy-2-oxoethyl)-1H-tetrazol-5-yl]isoxazol-3-yl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 1 h / 100 °C

3: triethylamine / tetrahydrofuran / 1 h / 80 °C

With sodium azide; ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; N,N-dimethyl-formamide;