ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

Base Information

Chemical Name:ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide
CAS No.:1092728-38-5
Molecular Formula:BrH*C₁₉H₂₇NO₄
Molecular Weight:414.34
Hs Code.:

Synonyms:ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

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Chemical Property of ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

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Technology Process of ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

There total 3 articles about ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 813445-18-0
ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-38-5
ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

Guidance literature:: ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate; With sodium tetrahydroborate; In isobutyric Acid; at 0 - 20 ℃;

With hydrogen bromide; In Isopropyl acetate; acetic acid; at 0 - 10 ℃; for 2h;

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1092728-38-5
ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux

2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

2.2: 2 h / 0 - 10 °C

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene; isobutyric Acid;

Reference yield:

: 121210-56-8
ethyl 8-hydroxy-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-38-5
ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux

2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

2.2: 2 h / 0 - 10 °C

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene; isobutyric Acid;