(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

Base Information

Chemical Name:(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester
CAS No.:1407507-32-7
Molecular Formula:C₂₇H₄₁NO₉
Molecular Weight:523.624
Hs Code.:

Synonyms:(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

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Chemical Property of (5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

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Technology Process of (5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

There total 4 articles about (5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407507-31-6
di-tert-butyl (5S)-2-[4-(benzyloxy)benzyl]-2-(benzyloxycarbonyl)-5-[(tert-butoxy-carbonyl)amino]hexanedioate

: 1407507-32-7
(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1407507-32-7
(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With N-Bromosuccinimide; hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 163210-89-7
tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate

: 1407507-32-7
(5S)-2-(tert-Butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)-hexanedioic acid 6-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; mineral oil;