N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

Base Information

• Chemical Name: N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide
• CAS No.: 681246-36-6
• Molecular Formula: C₁₆H₁₃BrFNO₃S
• Molecular Weight: 398.253

Synonyms:N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

Chemical Property of N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

There total 5 articles about N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-nitro-3,4-dihydro-2H-naphthalen-1-one (40353-34-2) → N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide (681246-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Fe; NH₄Cl / ethanol; H₂O

2: Br₂ / dimethylformamide; CHCl₃

3: pyridine / CH₂Cl₂

With pyridine; bromine; iron; ammonium chloride; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.03.085

Reference yield:

7-amino-1-tetralone (22009-40-1) → N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide (681246-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / dimethylformamide; CHCl₃

2: pyridine / CH₂Cl₂

With pyridine; bromine; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.03.085

Reference yield:

7-amino-8-bromo-3,4-dihydro-1(2H)-naphthalenone hydrobromide + 4-Fluorobenzenesulfonyl chloride (349-88-2) → N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide (681246-36-6)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/j.bmcl.2006.03.085

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

7-nitro-3,4-dihydro-2H-naphthalen-1-one

7-amino-1-tetralone

Downstream raw materials:

2-{[(4-fluorophenyl)sulfonyl]amino}-8-oxo-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

2-(4-fluoro-benzenesulfonylamino)-8-methyl-5,6,7,8-tetrahydro-naphthalene-1-carboxylic acid methyl ester

N-(1-bromo-8-methyl-5,6-dihydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 681246-36-6 N-(1-bromo-8-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-4-fluorobenzenesulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send