N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

Base Information

Chemical Name:N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]
CAS No.:1245795-18-9
Molecular Formula:C₃₃H₃₃N₃O₆
Molecular Weight:567.642
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

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Chemical Property of N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

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Technology Process of N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

There total 2 articles about N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 3705-42-8
Cbz-(L)-Glu-OBn

: 34288-06-7
(2-benzyloxy-phenyl)-hydrazine hydrochloride

: 1245795-18-9
N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.1016/j.bmcl.2010.06.013

Reference yield:

: 20012-63-9
o-(benzyloxy)aniline

: 1245795-18-9
N-(benzyloxycarbonyl)-L-glutamic acid 1-(benzyl ester) 5-[(2-benzyloxy-phenyl)-hydrazide]

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0 °C

1.2: 0 °C

2.1: O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium nitrite; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.11.012