(3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine

Base Information

• Chemical Name: (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine
• CAS No.: 1233192-48-7
• Molecular Formula: C₁₉H₂₈N₂O₂S
• Molecular Weight: 348.51
• Mol file: 1233192-48-7.mol

Synonyms:(3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine

Chemical Property of (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine

There total 7 articles about (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine + benzyl bromide (100-39-0) → (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine (1233192-48-7)

Guidance literature:

(3S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.3987/COM-10-11922

Reference yield: 70.0%

(3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine (1233192-51-2) + benzyl bromide (100-39-0) → (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine (1233192-48-7)

Guidance literature:

(3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.3987/COM-10-11922

Reference yield: 69.0%

(3S,6R)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine (1233192-50-1) + benzyl bromide (100-39-0) → (3S,6S)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzyl-6-methylsulfanylpyrazine (1233192-48-7)

Guidance literature:

(3S,6R)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.3987/COM-10-11922

upstream raw materials:

benzyl bromide

Dimethyldisulphide

(3S,6R)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-benzylpyrazine

(3S,6R)-2,5-diethoxy-3,6-dihydro-3-isopropyl-6-methylsulfanylpyrazine

Downstream raw materials:

6-benzyl-2,5-diethoxy-3-isopropylpyrazine